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Crotamiton

What is crotamiton?

Crotamiton is a topical medication used off label (extra label) to treat mites and relieve itchiness in birds. It is often used together with ivermectin.

Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. 

In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.

How do I give my pet crotamiton?

  • Crotamiton is applied topically to the skin and comes in a cream or lotion format.
  • Follow the instructions on the label of your product, in conjunction with your veterinarian’s directions.
  • Shake the product well before application.
  • Continue to use this medication for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.
  • Do not apply around the bird’s eyes or mouth.
  • The product is for external use, on the skin only. Make sure your pet does not groom or ingest the product after application.

Crotamiton should take effect within several hours, and improvement in clinical signs should follow.

What if I miss giving my pet the medication?

If you miss a dose of crotamiton, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects from crotamiton?

Crotamiton may cause the following side effects:

  • Irritation of the skin, rash, and an increase in itchiness
  • Irritation, nausea, vomiting, and abdominal pain if ingested orally

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This medication should stop working within 48 hours, although effects can be longer in pets with liver or kidney disease.

Are there any risk factors for this medication?

DO NOT USE crotamiton in:

  • Pets with skin that is suddenly inflamed
  • Pets with open or weeping skin wounds
  • Pets with a known sensitivity to this medication

Are there any drug interactions I should be aware of?

There are no documented drug interactions for crotamiton. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

  • At home, monitor for any side effects such as those noted above. If any side effects occur, discontinue use of the medication and contact your veterinarian.
  • Your veterinarian will let you know when they want to reassess your pet to ensure the medication is working and not causing side effects.

How do I store crotamiton?

  • Store at controlled room temperature of 68ºF–77ºF (20ºC–25ºC).
  • Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet’s weight and symptoms.


© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Last updated on Aug 29, 2025.